Job offer
Organisation/Company UMR 261 Research Field Chemistry Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 9 Apr 2026 - 22:00 (UTC) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 5 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
We discovered that palmatine (PAL), a well‑known natural product, was inducing the fluorogenic fixation of live cells upon visible light irradiation. This ultrafast phenomenon proceeded under high spatiotemporal control down to single cells (SC), with persistence of well‑preserved fixed‑labeled cells. Cell optofixing was mediated by PAL interaction with nuclear and mitochondrial DNA, yielding reactive oxygen species (ROS) mainly singlet oxygen (1O2), lipid peroxidation (LPO) and LPO‑derived fixing aldehydes. We found that other DNA dyes including conventional trackers were also capable of optofixing cells, furnishing a consistent methodology (fluorophore‑mediated optofixation, FLUMO) across the visible spectrum.
The aim of the PhD project is to semisynthesize novel fluorogenic optofixatives with improved photobiological properties forapplications in SC, organoid and whole organism biology at the level of partnering parisian institutes (I. Curie and I. Pasteur).
- Outstanding track record (grade A in French license, M1 and M2 or equivalent)