Identification of lanthanide protein interactions in mammalian cells

Organisation/Company Université Grenoble-Alpes Department CBH Graduate school Research Field Chemistry » Other Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 15 Apr 2026 - 23:59 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Context: Recent technological developments have expanded and intensified the use of lanthanides (Ln) in domains as diverse as renewable energy, computing, and medicine. The increasing usage of these metals raises the question of their impact on the environment and human health. However, the potential toxicity of these metal ions, and its underlying molecular mechanisms, are still little known and rarely investigated in human cell models. Identifying direct metal-protein interactions in cell is key to answer these questions, yet it is also a challenge due to the labile character of these interactions.

Project

Project: We aim to identify the protein interactome of lanthanide ions (lanthanoproteome) by combining molecular tools and proteomic approaches. The postdoc will synthesize molecular tools to enrich and/or label covalently proteins interacting with Ln(III) ions. He or she will assess the efficacy of these molecular tools on isolated proteins, then implement these tools in mammalian cells to identify the interactome of lanthanide ions by mass‑spectrometry‑based proteomics.

Position Details

Position details:

• Location: The postdoc candidate will be part of a collaborative project between two research groups in Grenoble, France: the CIBEST team of the SyMMES lab (synthesis, in‑vitro proof‑of‑concept, toxicology) and the EDyP team of the BGE lab (proteomic analysis).
• Funding: 2-year funding by EUR-CBH Graduate school. Salary in agreement with the postdoctoral salary guidelines of Université Grenoble Alpes.
• Starting date: October 1st, 2026.
• Profile: The candidate should have a PhD degree in chemical biology, bio‑organic chemistry, bio‑inorganic chemistry or a related field at the beginning of the postdoc. He or she should have skills in organic synthesis, and a strong motivation for collaborative work at the chemistry‑biology interface. Experience in protein biochemistry, cell culture or proteomics would be a plus but is not required.
• Languages: ENGLISH Level Good.

Research Field: Chemistry > Molecular chemistry / Biological sciences > Other.

Internal Application form(s) needed.

Postdoc-position_Grenoble_France_lanthanide_proteomics.pdf