Translational PK/PD Modeler -CDI- F/M

About the Company

Pierre Fabre Laboratories is a leading pharmaceutical and dermo-cosmetics company.

Position Overview

We are seeking a Translational PK/PD Modeler to join the PKPD/Tox Modeling & Simulation Team within R&D Pharma at Pierre Fabre Laboratories in Toulouse (Langlade site, Oncopole).

Responsibilities

• Provide strategic translational leadership and translate findings into clear recommendations to drive critical decisions across discovery and early clinical development.
• Develop and apply advanced PK/PD models with a focus on oncology programs to guide candidate selection, interspecies extrapolation, FIH dose selection, and mechanistic understanding of exposure‑response relationships.
• Evaluate PK/PD relationships across invitro, invivo, and emerging clinical data to assess translatability and identify potential disconnects.
• Provide quantitative support for IND submissions, including nonclinical pharmacology sections and FIH dose justification.
• Communicate PK/PD modeling results to diverse stakeholders and actively influence decision‑making in project teams.
• Identify opportunities where translational PK/PD modeling can contribute to a better understanding of efficacious exposure and dosing strategies.
• Educate cross‑functional teams on translational modeling capabilities and appropriate use of quantitative tools.
• Collaborate with Clinical Pharmacologists and Pharmacometricians to ensure seamless handoff and continuity of modeling strategy into later clinical development.
• Contribute to scientific publications and present at internal or external scientific conferences to establish thought leadership.

Required Qualifications

• PhD in Pharmaceutical Sciences, Computational Biology, Applied Mathematics, or a related quantitative field.
• Minimum 5+ years of post‑PhD experience in preclinical/translational PK/PD modeling in the pharmaceutical or biotech industry.
• Expert‑level knowledge in preclinical PK/PD with strong experience in oncology‑relevant PK/PD models (e.g., TGI models, resistance/adaptation models, survival models, time‑to‑event models, systems pharmacology models).
• Strong proficiency in programming languages such as R, MATLAB, or Python, and at least one relevant modeling software (e.g., Monolix, NONMEM, PK‑Sim).
• Strong understanding of oncology drug development, including preclinical model systems, biomarkers, and clinical endpoints.
• Understanding of regulatory expectations (e.g., ICHS9, FDA guidance on dosage optimization for oncologic diseases).
• Strong scientific writing skills and experience in contributing to regulatory submissions (INDs) and scientific publications.
• Comfortable with ambiguity and ability to make pragmatic decisions with incomplete data.
• Excellent interpersonal skills and ability to work in cross‑functional teams.
• Excellent written and verbal skills in English.

Preferred Qualifications

• Demonstrated scientific leadership through a publication track record in oncology.
• Experience in PBPK and quantitative systems pharmacology (QSP) models.
• Experience in modeling multiple therapeutic modalities beyond small molecules (biologics, targeted therapies, ADCs).
• Experience mentoring junior scientists and leading technical workstreams.

Benefits

• Incentives and profit‑sharing.
• Pierre Fabre shareholding with matching contribution.
• Health and provident insurance.
• 16 days of RTT holidays + 25 days of personal holidays.
• Participation in public transport subsidy.
• Position compatible with teleworking up to 2 days a week (company rules).

Diversity & Inclusion

We are convinced that diversity is a source of fulfillment, social balance, and complementarity for our employees; our offers are open to all, without restriction.