Principal Scientist Crystallization & Particle Engineering

Principal Scientist – Crystallization & Particle Engineering

Location: Montpellier, France

We are looking for an experienced scientist to lead our Crystallization & Particle Engineering Laboratory, driving innovative projects across Sanofi’s small‑molecule portfolio from early‑stage discovery all the way to commercialization.

Responsibilities

• Define and implement the laboratory’s scientific strategy in crystallization and particle engineering for small‑molecule APIs and drug products across development stages.
• Develop and optimize innovative crystallization processes (batch, continuous, reactive) and push technological boundaries for complex small molecules.
• Explore and apply new particle‑engineering techniques (spray drying, milling, granulation, hot‑melt extrusion, etc.) and leverage modeling/simulation to predict crystallization behavior.
• Identify and evaluate polymorphs and crystalline forms, optimizing bio‑availability and manufacturability.
• Apply QbD and PAT principles from discovery through commercialization; scout and integrate new technologies to maintain competitive advantage.
• Lead the seamless technology transfer of processes from early development to large‑scale production, collaborating with production teams and ensuring GMP and quality documentation.
• Collaborate with cross‑functional teams (Formulation, Analytical Sciences, Chemical Development, Manufacturing) and provide scientific expertise in project meetings and strategic committees.
• Represent the laboratory at scientific conferences, contributing to publications and patents.
• Lead and develop a team of 3‑5 scientists/engineers, conduct annual reviews, and manage laboratory budget and resources.
• Ensure compliance with EHS standards, GMP guidelines, and maintain state‑of‑the‑art scientific equipment.

Qualifications

• PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related field.
• Solid expertise in crystallization, solid‑state chemistry, or particle engineering for small molecules.
• In‑depth experience with crystallization process development and polymorphism across early and late stage development.
• Advanced mastery of particle‑engineering technologies (spray drying, milling, granulation, etc.).
• Confirmed experience in QbD, PAT, and process optimization.
• Experience leading scientific teams and fostering innovation.
• Excellent scientific communication skills and collaborative mindset.
• Fluency in English and French.
• Scientific publications and/or patents in the field (highly desired).

Benefits

• Competitive fixed salary (€54400–€72533) plus profit‑sharing and incentive bonuses based on group results.
• 31days paid leave plus RTT days; remote work up to 2days/week.
• Health insurance, public transportation coverage up to 80%, maternity and child‑welcoming leave.
• Retirement plans with employer contributions, savings plan, and works‑council benefits.
• Internal and international mobility opportunities and a customizable training program.
• Access to state‑of‑the‑art facilities and cutting‑edge scientific equipment.

Equal Opportunity Statement

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, or protected veteran status. Activities and benefits are offered on a merit‑based basis.