Lead researcher position in Onco-hematology

The lead researcher will develop and lead independently a research project applied to the two main pathophysiological models of CD5+ chronic B cell neoplasms (chronic lymphocytic leukemia and mantle cell lymphoma) of the host laboratory (SIMHEL/U1349). The project conducted by the junior professor will bring new lines of research and synergize with ongoing SIMHEL research axes on 1) the mechanisms at the basis of the tumor cells plasticity between quiescent and proliferative stages, where immunoregulatory functions are acquired, 2) the tolerogenic and metabolic mechanisms underlying the retention of a proliferative pool of leukemic cells in sanctuary lymphoid organs leading to transformation in high-grade lymphomas. 3) computational prediction tools of progression and new preclinical models to target the resistance to current therapeutic options. The research program will favor translational approaches; the experimental design will benefit from technological facilities available on site (OMICS, functional genomics, multiparameter flow cytometry, multiplex, 3D-cell cultures) as well as fully annotated patient’s blood samples and biopsies collected at the “Center for biological resources” and hematology department.

Teaching Activities

The teaching project includes advanced programs of USPN and University Paris Cité:

• Bachelor (L3) level in biochemistry, molecular biology and genetics
• Master levels: M1 and M2 T2V and international IMI, Infibrex
• Specialized teaching at the Doctorate level (Training at Ecole Doctorale Galillée)
• Module of onco-hematology
• European network on hematology (ERIC and European School of Hematology)

The ‘Chaire INSERM’ will also contribute to our training of medical and pharmacist researchers (medical faculty) and to the international attractiveness of our teaching program. Innovative teaching practices will be appreciated.