Job offer

Organisation/Company: INSERM Department U1011 (Research Field: Biological sciences – Biology). Profile: First Stage Researcher (R1). Positions: Postdoc Positions. Application Deadline: 28 Feb :59 (Europe/Brussels). Country: France. Type of Contract: Temporary. Job Status: Full-time. EU Research Funding: Not funded. Research Infrastructure: No.

Offer Description

I am seeking a motivated post-doctoral fellow to join a multidisciplinary project investigating how vascular remodeling shapes liver fibrosis progression, regression, and regeneration. The project focuses on cellular and molecular mechanisms that drive sinusoidal endothelial cell (LSEC) plasticity, their cross‑talk with hepatocytes and ductular reaction (DR) cells, and how these interactions determine regenerative capacity. Using advanced imaging, spatial transcriptomics, and innovative 3D culture systems, the project aims to uncover how fibrosis‑induced vascular changes impair liver regeneration and how re‑establishing sinusoidal integrity can restore function.

You will join the newly created ATIP‑Avenir team of Dr. Rita Manco, based at INSERM UMR1011. We are a young, growing, and highly motivated group working to understand how vascular remodeling controls liver fibrosis and regeneration.

The project will be performed in UMR1011, a research unit affiliated to the laboratory of excellence‑labeled European Genomic Institute of Diabetes (EGID), INSERM, Institut Pasteur de Lille, CHU de Lille and Lille University. The unit develops interdisciplinary research at the interface of physiology, cell biology, biochemistry and medicine, hosts state‑of‑the‑art scientific technological platforms. It is a stimulating and highly collaborative environment.

We offer a two‑year contract funded by the ATIP‑Avenir program, starting in February 2026 (flexible). Salary and social benefits follow the official INSERM scales. The position provides opportunities for independence, international networking, and leadership development in preparation for future fellowships.

Where to Apply

E‑mail:

Requirements

Research Field: Biological sciences – Biology. Education Level: PhD or equivalent.

Skills / Qualifications: Applicants should hold a PhD in biological or life sciences obtained within the past two years and have a solid background in cell and molecular biology, including primary cell culture and ideally some experience with 3D systems. Familiarity with spatial or transcriptomic approaches and image analysis would be an advantage. We are looking for someone motivated to work in an interdisciplinary environment with good communication skills in English.

Responsibilities

• Design and execute experiments in mouse models of liver disease.
• Establish and optimize 3D culture models to explore endothelial–epithelial cross‑talk.
• Perform imaging and spatial transcriptomics; contribute to data analysis & interpretation.
• Write and present results (manuscripts, conferences).

Selection Process

Candidates should send to a CV with publication list, short summary of previous research achievements (1 page) and names and contact details of at least two referees.