Job offer

Pharmacological sciences » Clinical pharmacology

Organisation/Company INSERM 1116 Research Field Medical sciences » Health sciences Biological sciences » Biology Pharmacological sciences » Clinical pharmacology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 30 Apr 2026 - 17:00 (UTC) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Sep 2026 Is the job funded through the EU Research Framework Programme? Horizon Europe - MSCA Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Lipids are of vital importance through integration in cell membranes, as energy source and in cellular signaling and function. As such, they also play decisive roles in cardiovascular disease, chronic kidney disease, cancer and chronic inflammatory disease. These diseases affect 33%, 60%, 10% and 33% of Europeans, and are responsible for >60% of global deaths. The European Doctoral Network LipidBRIGHT combines scientists, clinicians, companies and stakeholder organisations with expertise in these disease fields. By integrating expertise in lipids from the clinical, biomedical, technological and data science field across disease borders and by transferring complementary knowledge and technology, LipidBRIGHT aims to speed up innovations towards improved disease prevention, diagnosis, prognosis and therapy. LipidBRIGHT will train scientists in a close cooperation between academia, SMEs and industry partners. Key objectives are to provide:

1) Excellent scientific training on interdisciplinary level, covering lipid biochemistry and pathophysiology as well as clinical application

2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research

3) Exposure to both academic and non- academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative products and services.

LipidBRIGHT builds on available patient cohorts, advanced technologies and established cooperations and strives to synergistically improve structural training on European level. LipidBRIGHT will nurture the development of young, broadly-trained scientists able to successfully bridge clinical with basic research as well as academia and industry, which is a cornerstone in effectively combatting complex diseases as cardiovascular disease, chronic kidney disease, cancer and chronic inflammatory disease. For more information:

Cardiovascular disease (CVD) is the leading cause of death in Europe and a major public health concern, affecting over 49 million people and costing the EU approximately €200 billion annually. Despite advances in treatment, lifestyle-related challenges continue to complicate CVD management. Chronic inflammation, particularly in atherosclerotic cardiovascular disease (ASCVD), is a key issue. It arises from ineffective resolution of inflammation, leading to plaque instability and potentially severe events such as heart attacks and strokes. While lifestyle interventions, including a healthy diet and regular physical activity, can help control inflammation, elevated blood lipid levels remain a significant risk factor. Lipid-lowering therapies are effective, yet residual inflammation continues to pose a threat. Consequently, dietary strategies aimed at regulating lipids may complement existing preventive measures and provide new opportunities to tackle chronic inflammation and reduce cardiovascular risk.

The PhD student will investigate the mechanisms underlying the resolution of chronic lipid-driven vascular inflammation using in vivo and in vitro approaches. The project aims to identify and validate functional, molecular and immune‑metabolic targets capable of diagnosing, preventing, and treating the transition from health to CVD by promoting effective inflammation resolution.

Where to apply

E-mail

Requirements

Research Field Biological sciences » Biology Education Level Master Degree or equivalent

Skills/Qualifications

• MSc degree in Physiology, Life Sciences, Medical/Pharmaceutical Sciences, or a related field
• Strong background in Molecular Biology and Histology
• Experience in Biochemistry, Mass Spectrometry, and Flow Cytometry
• Experience in Proteomics and Metabolomics is highly advantageous
• Fluency in written and spoken English
• Knowledge of French is appreciated
• Strong organizational skills, dedication, proactiveness, and willingness to participate in networking activities

• Prior experience in Cardiology research is highly advantageous

Languages FRENCH Level Basic

Research Field Biological sciences » Biology Years of Research Experience None

Additional Information

The doctoral candidate (DC) will receive a 36-month scholarship intended to cover living expenses. The amount of the scholarship is based on a monthly living allowance, adjusted through a country correction coefficient reflecting the cost of living in the host country. The final amount will be determined based on the candidate’s family situation, in accordance with MSCA rules. All training activities will be fully covered by the network through the Horizon Europe MSCA-DN grant, including travel and accommodation costs for annual meetings and other network-organised events. DCs will have access to a dedicated workspace and research facilities. Costs related to consumables and the execution of the research project will be covered by the host institutions.

Eligibility criteria

According to the EU rules for the DN projects, the recruited researchers must comply with the following conditions:

Eligibility criteria :

1- Are at the date of recruitment doctoral candidates (DCs) (must NOT have a doctoral degree)

2- DCs can be of any nationality

3- Must comply with the following mobility rule: not have resided in the country of the recruiting beneficiary for more than 12 months in the 36 months immediately before the recruitment date (and not have carried out their main activity (work, studies, etc.) in that country)- unless as part of a procedure for obtaining refugee status under the Geneva Convention. For beneficiaries that are international European interest organisations or international organisations: not have spent with the beneficiary more than 12 months in the 3 years immediately before the recruitment date.

before 30 April 2026 at 17:00 Central European time.

Please include:

• A curriculum vitae and a cover letter

• Your MSc transcript (degree certificate, courses, and grades)

• One letter of reference and the contact details of your academic supervisor/referee