Distinguished Scientist – Transgenic Model & Technology

Senior Distinguished Scientist – Transgenic Model & Technology - CDI Location: Montpellier / Vitry-sur-Seine, France Candidates must be willing to travel internationally as part of this position

About the job

As Senior Distinguished Scientist within our Translational In Vivo Models (TIM) team, you'll lead our global Transgenic Model & Technology function and drive innovation in genome engineering to accelerate drug discovery across all therapeutic divisions. Ready to get started? Join the engine of Sanofi's mission where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions.

About Sanofi

The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Senior Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions. As the global head of Transgenic Biology, you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies, including AI and digital platforms — into transgenic science.

Main responsibilities

• Lead and advance state-of-the-art genome engineering and CRISPR-based strategies for in vivo model development, covering immunology, rare diseases, neuroscience, and oncology.
• Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms.
• Champion AI and digital integration to enhance model design, data analysis, and predictive capabilities in transgenic research.
• Serve as strategic scientific advisor to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design.
• Align transgenic capabilities with organizational research priorities and long‑term scientific goals through strategic planning and cross‑functional leadership.
• Lead transversal teams and projects across multiple therapeutic divisions, sites, and external partners, collaborating with program leaders, cluster heads, and department heads.
• Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency.
• Build and manage strategic partnerships with model providers, CROs, and academic partners, including negotiation of license agreements and contracts.
• Supervise, mentor, and develop a high‑performing team, fostering a culture of scientific excellence, innovation, and continuous learning.

What we offer you:

• A fixed salary over 12 months, supplemented by a short‑term incentive, as well as a collective variable compensation based on Sanofi Group results.
• 31 days of paid leave + RTT depending on your status, remote work up to 2 days/week, quality health insurance, public transport coverage up to 80%, extended maternity/parental leave (18/14 weeks), Group Savings Plan & PERCOL with employer matching, PERO, numerous CSE benefits, internal and international mobility opportunities, learning & development opportunities, and many other benefits to discover here.

Why choose us?

Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real‑world needs. Work at the forefront of drug discovery, harnessing cutting‑edge AI, data, and digital platforms to push the boundaries of science. Lead a unique global department critical to ALL drug development — no compound enters clinical trials without your team's support. Accelerate your professional development with structured career paths and potential succession planning opportunities. Collaborate with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs. Achieve genuine work‑life balance in a supportive R&D environment with comprehensive benefits. Pursue Progress. Discover Extraordinary. Join Sanofi and step into a new era of science - where your growth can be just as transformative as the work we do.

Experience:

• Extensive post‑doctoral or industry experience in mouse molecular genetics and transgenic animal model development
• Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment

Technical skills:

• Deep expertise in developing transgenic animal models, including engineering diverse genetic alleles using CRISPR/Cas9, Cas12, base editors, prime editors, and other advanced genome engineering systems
• Comprehensive knowledge of both theoretical principles and practical methodologies required to lead a state‑of‑the‑art transgenic facility
• Strong foundation in molecular biology, mouse genetics, embryology, and reproductive technologies
• Experience across multiple therapeutic areas (immunology, oncology, rare diseases, neuroscience preferred)
• Familiarity with AI and digital technologies in biological research, model design, and data analysis

Soft skills:

• Proven strategic thinking with ability to align scientific capabilities with business objectives
• Demonstrated success leading transversal teams across sites and functions
• Self‑motivated with demonstrated ability to lead and thrive in collaborative team environments
• Comfortable managing competing priorities and adapting to dynamic research needs
• Commitment to scientific excellence, integrity, and ethical research practices
• Passion for mentoring and developing scientific talent

Education:

• Ph.D. in Molecular Biology, Genetics, Developmental Biology, or related discipline.

Languages:

• English fluency required for global collaboration

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com! The salary range for this position is :€76 000,00 - €101 333 Final compensation will be determined based on demonstrated experience, skills, location, and other relevant factors. Employees may be eligible to participate in Company employee benefit programs. We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world. Discover more about us visiting or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug‑discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.