Chromatin-Metabolism-Glycosylation interplay in immune recognition

Biological sciences » Biological engineering

Biological sciences » Biology

Biological sciences » Laboratory animal science

Biological sciences » Nutritional sciences

Biological sciences » Other

Organisation/Company Universite de Montpellier Department Human Resources Research Field Biological sciences » Biological engineering Biological sciences » Biology Biological sciences » Laboratory animal science Biological sciences » Nutritional sciences Biological sciences » Other Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 3 Apr 2026 - 23:59 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Horizon Europe Reference Number 2026-R0180 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

- work environment: IRCM offers a high‑caliber research environment at the intersection of fundamental and translational cancer biology. It brings together leading teams in chromatin regulation, metabolism, immunology, and translational oncology, supported by top‑tier core facilities in genomics, proteomics, metabolomics, imaging, and in vivo models. Embedded within the Montpellier Cancer Research ecosystem and backed by Inserm, Montpellier University and ICM, IRCM provides exceptional scientific resources, strong clinical connections, and a culture that values ambition, rigor, and collaboration. Our group is a growing, highly‑collaborative team composed of two postdoctoral researchers, one PhD student, one research technician, and rotating students who contribute to specific projects throughout the year. We operate with a strong emphasis on rigorous experimental design, collaborative problem‑solving, and intellectual independence. The lab culture is dynamic and supportive, offering close mentorship alongside the freedom to drive ambitious, mechanistic projects at the interface of chromatin biology, metabolism, immune regulation and cancer.

- main mission: We explore the molecular regulation of immune‑repressive cues produced by host tissues to enforce immune tolerance. Dysregulation of these pathways contributes to autoimmune pathogenesis and enables tumor cells to evade immune detection. We investigate how chromatin‑remodeling complexes modulate transcriptional control of metabolic flux, with a particular emphasis on the impact on glycosylation pathways and the secretory/trafficking machinery required for intercellular immune communication.

We develop and integrate multi‑omics pipelines—genomics, metabolomics, glycoproteomics—with targeted genetic and biochemical perturbations. Our experimental systems include Drosophila melanogaster , mammalian cell lines, and forthcoming murine models, enabling mechanistic dissection across evolutionary scales. This framework allows us to define causal links between chromatin state, metabolic pathway architecture, glycan output, and immune‑modulatory signaling in both homeostasis and cancer.

The net monthly salary is €2,380

The contract duration is 18 months

Where to apply

E-mail

Requirements

Research Field Biological sciences » Biology Education Level PhD or equivalent

Skills/Qualifications

We are seeking an intellectually bold and technically accomplished scientist who is ready to drive frontier‑level research at the interface of chromatin biology, metabolism, glycoscience, and immune regulation. The ideal candidate brings deep expertise in one or more of the following domains and the curiosity to push beyond disciplinary boundaries:

• Chromatin genomics — CUT&RUN, with the computational sophistication to independently analyze, integrate, and interpret genome‑wide chromatin landscapes.
• Metabolomics and isotope tracing — hands‑on experience with LC‑MS instrumentation, heavy isotope tracing analysis, and the ability to extract mechanistic insight from complex metabolic data.
• Glycoscience — strong grounding in glycomics and/or glycoproteomics, with an interest in connecting glycan architecture to immune communication and tissue homeostasis.

Model‑system immunology and cancer biology — expertise in Drosophila immunity, mammalian immune pathways, cancer immunity, or cancer metabolism.

• Curriculum Vitae, including a complete list of publications
• Cover letter detailing research accomplishments, scientific interests, and alignment with the laboratory’s objectives
• Two reference letters (preferably), or alternatively the names and contact information of two referees able to provide confidential evaluations
• If reference letters are not included in the initial application, referees may be contacted directly during the selection process.

Applications will be reviewed on a rolling basis. Shortlisted candidates will be contacted for an interview.

Work Location(s)

Number of offers available 1 Company/Institute Institut de Recherche en Cancérologie de Montpellier (IRCM) Country France Geofield