Characterization of Autoantibodies in Patients with PLA2R1-Associated membranous Nephropathy (M/F)

Organisation/Company CNRS Department Institut de Pharmacologie Moléculaire et Cellulaire Research Field Pharmacological sciences Engineering Technology Researcher Profile Recognised Researcher (R2) Application Deadline 25 Sep 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The researcher will independently conduct the characterization of autoantibodies in patients with PLA2R1-associated membranous nephropathy, from molecular characterization through in vitro and in vivo studies.

• Produce various antigens (PLA2R1 and its fragments) in recombinant form.
• Produce monoclonal antibodies from patients in the form of mAb, Fab, and scFv.
• Characterize the molecular and functional properties of the interactions between PLA2R1 and patient antibodies, both in vitro and in vivo.
• Develop inhibitors of these interactions and validate them in various assays.
• Present results, interpret data, validate findings, and take initiative independently.

Recruitment for this position is open as part of a program funded by the ANR and other sources. The researcher will work in the team Molecular Pathophysiology of Phospholipase A2 and Its Mediators, under the direct supervision of the team leader. The team is studying PLA2s and their receptor PLA2R1, which are therapeutic targets for various inflammatory and autoimmune diseases.The IPMC is a multidisciplinary institute with approximately 200–250 staff members, comprising 20 research teams.The employee will be trained on the potential risks associated with the project by the team leader upon arrival at the laboratory. The employee will also receive the employee training provided by the biological and chemical risk prevention assistants.

• Extensive experience in molecular and cellular biology, protein engineering, and recombinant production in prokaryotic and eukaryotic systems, ideally involving antibodies and secreted proteins with disulfide bonds
• Ability to work independently and as part of a team
• Strong organizational skills
• Attention to detail and rigor
• Skills:
• In-depth mastery of techniques in structural and molecular biology, biochemistry, cell biology, and immunology is essential.
• Proficiency in using computer tools and software dedicated to data processing and the presentation of results.